BP301T. PHARMACEUTICAL ORGANIC CHEMISTRY –II.
Scope: This subject deals with general methods of preparation and reactions of some organic compounds. Reactivity of organic compounds are also studied here. The syllabus emphasizes on mechanisms and orientation of reactions. Chemistry of fats and oils are also included in the syllabus.
SYLLABUS
UNIT – I
Benzene and its derivatives
A. Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule
B. Reactions of benzene – nitration, sulphonation, halogenation reactivity, Friedel crafts alkylation- reactivity, limitations, Friedel crafts acylation.
C. Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction.
D. Structure and uses of DDT, Saccharin, BHC and Chloramine
UNIT – II
A. Phenols* – Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols
B. Aromatic Amines* – Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts
C. Aromatic Acids* – Acidity, effect of substituents on acidity and important reactions of benzoic acid.
UNIT – III
Fats and Oils
a. Fatty acids – reactions.
b. Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.
c. Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and principle involved in their determination.
UNIT – IV
Polynuclear hydrocarbons:
a. Synthesis, reactions
b. Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene,
Diphenylmethane, Triphenylmethane and their derivatives
UNIT – V
Cyclo alkanes*
Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only.
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Pharmaceutical Organic Chemistry-II FAQ‘s (Frequently Asked Questions)
Unit-1:
1. Discuss the reactions and Mechanism of ESR of Benzene (Halogination, Sulfonation / Friedel Crafts Reaction with Limitations.
2. Write about following
a) Resonance in benzene b) Huckel’s rule & Kekule Structure c) Orbital Structure of Benzene
d) Explain the Orientation of Mono Substituted Benzene with Effect of Substituents & Activity
3. Write the Structure and Uses of DDT, Saccharin, BHC and Chloramine
Unit-2:
4. Discuss the Acidity of phenols, effect of substituents on acidity, Qualitative tests of Phenol
5. Write the Structure and uses of Cresol, Resorcinol, naphthols, Phenol
6. Explain basicity of Amines and Discuss the Diazotization reaction, write the synthetic uses.
7. Discuss different chemical reaction of benzoic Acid and Explain Acidity of benzoic Acid.
Unit-3:
8. Define Fats & Oils. What is the chemical character of Fat? How they will differ from oil and Waxes? Discuss the chemical reactions of Fatty Acids with suitable examples?
9. Write a descriptive note on analytical constants of Fats and Oils (Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value), Drying Oil.
10. Discuss Hydrolysis, Hydrogenation, Saponification and Rancidity of oils reaction of Fats
Unit-IV:
11. Give the detail note on Napthalene and Anthracene. Write the Structure, Uses, Preparation and Chemical Reactions of Napthalene and Phenanthrene
12. Give the Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane
Unit-V:
13. Define Angle Strain, Explain Baeyer’s strain theory, discuss limitation of Baeyer’s strain theory
14. Write detail note on Sachse Mohr Theory and Coulson and Moffitt’s modification
15. Write the Preparation and reactions of cyclopropane and cyclobutane.
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