SYLLABUS OF PHARMACEUTICAL ORGANIC CHEMISTRY –I (Theory) (SUBJECT CODE: BP202T).
Mandatory Note:
- General methods of preparation and reactions of compounds superscripted with asterisk (*) to be explained.
- To emphasize on definition, types, classification, principles / mechanisms, applications, examples and differences
UNIT-I
- Classification, nomenclature and isomerism
Classification of Organic Compounds
Common and IUPAC systems of nomenclature of organic compounds
(up to 10 Carbons open chain and carbocyclic compounds)
Structural isomerisms in organic compounds
UNIT-II
- Alkanes*, Alkenes* and Conjugated dienes*
SP3 hybridization in alkanes, Halogenation of alkanes, uses of paraffins. Stabilities of alkenes, SP2 hybridization in alkenes
E1 and E2 reactions – kinetics, order of reactivity of alkyl halides, rearrangement of carbocations, Saytzeffs orientation and evidences. E1 verses E2 reactions, Factors affecting E1 and E2 reactions. Ozonolysis, electrophilic addition reactions of alkenes, Markownikoff’s orientation, free radical addition reactions of alkenes, Anti Markownikoff’s orientation.
Stability of conjugated dienes, Diel-Alder, electrophilic addition, free radical addition reactions of conjugated dienes, allylic rearrangement
UNIT-III
- Alkyl halides*
SN1 and SN2 reactions – kinetics, order of reactivity of alkyl halides, stereochemistry and rearrangement of carbocations.
SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions.
Structure and uses of ethylchloride, Chloroform, trichloroethylene, tetrachloroethylene, dichloromethane, tetrachloromethane and iodoform. - Alcohols*- Qualitative tests, Structure and uses of Ethyl alcohol, Methyl alcohol, chlorobutanol, Cetosteryl alcohol, Benzyl alcohol, Glycerol, Propylene glycol
UNIT-IV
- Carbonyl compounds* (Aldehydes and ketones)
Nucleophilic addition, Electromeric effect, aldol condensation, Crossed Aldol condensation, Cannizzaro reaction, Crossed Cannizzaro reaction, Benzoin condensation, Perkin condensation, qualitative tests, Structure and uses of Formaldehyde, Paraldehyde, Acetone,
Chloral hydrate, Hexamine, Benzaldehyde, Vanilin, Cinnamaldehyde.
UNIT-V
- Carboxylic acids*
Acidity of carboxylic acids, effect of substituents on acidity, inductive effect and qualitative tests for carboxylic acids ,amide and ester
Structure and Uses of Acetic acid, Lactic acid, Tartaric acid, Citric acid, Succinic acid. Oxalic acid, Salicylic acid, Benzoic acid, Benzyl benzoate, Dimethyl phthalate, Methyl salicylate and Acetyl salicylic acid - Aliphatic amines* – Basicity, effect of substituent on Basicity. Qualitative test, Structure and uses of Ethanolamine, Ethylenediamine, Amphetamine
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Subject: Pharmaceutical Organic Chemistry-I
FAQ‘s (Frequently Asked Questions) (Important Questions)
1. a) What are Organic Compounds, Classify them with suitable Examples. And write IUPAC System of Nomenclature.
b) Define Isomerism, Classify the Structural isomerism with suitable Examples
2. Explain E1 and E2 Reactions, Differentiate E1 Versus E2 and also mention the factors affecting E1 and E2 Reaction.
3. Write the Following: 2 Marks or 5 Marks
- Ozonolysis of Alkenes
- Diels – Alder reaction with Mechanism
- Allylic rearrangement
- Markownikoff’s Rule & Anti Markownikoff’s Rule (Peroxide Effect), Saytzeffs Rule
- Electrophilic Addition & Free radical addition reactions of alkenes & Conjugated Dienes
- Sp3 Hybridization of Alkane & Sp2 Hybridization of Alkene
- Halogination and stability Order of Alkanes
- Electromeric effect of Carbonyl Compounds
- Inductive effect
- Stability of Carbocations
- Quality Test for Aliphatic Amines
- Stability of Conjugated Dienes
4. Explain the SN1 & SN2 Reaction with kinetics, order of reactivity, stereochemistry, Differentiate SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions.
5. Write the Preparation and Chemical reactions of Alcohols. Discuss Qualitative tests of Alcohol.
6. Write structure and uses of Trichloroethylene, Paraffins, dichloromethane, chlorobutanol, Cetosteryl alcohol, Benzyl alcohol, Glycerol, Propylene glycol, Chloroform, iodoform, Chloral hydrate.
7. a) Explain Nucleophilic addition in Carbonyl Compounds
b) Write the following Reactions with Mechanism i) aldol condensation ii) Cannizzaro reaction iii) Perkin condensation iv) Benzoin condensation (Including Crossed Reactions Also)
8. Explain Basicity of Amines Discuss with effect of substituent, write the structure and uses of Amphetamine, Ethanolamine, Ethylenediamine, Chloral hydrate, Hexamine, Benzaldehyde, Vanilin, Cinnamaldehyde, Paraldehyde
9. Explain Acidity of carboxylic acids with effect of substituents. Write the Qualitative Tests of carboxylic Acids, Esters & Amide.
10. Write structure and uses of Lactic Acid, Citric Acid, Tartaric Acid, Oxalic Acid, Salicylic acid, Benzoic acid, Benzyl benzoate, Dimethyl phthalate, Methyl salicylate and Acetyl salicylic acid
DOWNLOAD IMPORTANT QUESTIONS PDF – CLICK HERE
PREVIOUS YEAR EXAM QUESTION PAPERS – CLICK HERE
If read all above Questions, it will be cover all 2 marks, 5 marks & 10 mark Questions from All Chapters.
PREPARED BY:
S.SEETARAMSWAMY, M.Pharm
Dept. of Pharmaceutical Chemistry
GCP, SIKAR, RAJASTHAN.
E-Mail: seetaram.443@gmail.com
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