Pharmaceutical Questions and Answer for Interview
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1. What is Production?
- All the activities involved in the manufacturing of a pharmaceutical product starting from receipt of raw materials to the completion of a finished product means, from Raw material Receipt to Finished product dispatch.
- It contains the handling of manpower and recording of the manufacturing and the packing activity.
2. What is Batch Manufacturing Record(BMR)
- BMR is a Document that provides a history of a batch mean how a product is manufactured step by step following written procedures.
- It contains signs of qualified persons and operators involved in manufacturing.
3. What is Batch packaging Record (BPR)
- Batch packaging record or BPR is the document that provides a history of batch packaging and in-process checks of Packaging.
4. Define Tablet
- Tablet is a solid dosage form prepared by a combination of API and Excipients by application of pressure.
5. What is API
- API stands for Active pharmaceutical ingredient.
- API is a substance that gives pharmacological effects.
6. What is Excipient
- Inert materials which do not give any pharmacological effect.
7. Classification of Excipients for Solid Dosage form
- Diluents
- Binders
- Disintegrants
- Glidents
- Lubricants
- Colourants
- Flavours
8. Tests for Tablet
- Weight variation
- Thickness
- Hardness
- Friability
- Disintegration
- Dissolution
- Assay
- Content uniformity
9. what are Defects of Tablet
- Capping
- Lamination
- Sticking
- Picking
- Weight Variation
10. What is Disintegration
- The time needed for tablet or capsule to break down into particles which pass through # 10 mesh and no solid mass is left.
11. What is Disintegration Time of Capsules
- 30 Min.
12. What is Disintegration Time of uncoated tablet
- Not more than 15 minutes.
13. What is Disintegration Time of Film-coated tabs?
- Not more than 30 minutes.
14. What is Disintegration Time sugar-coated tablets?
- Not more than 60 minutes.
15. What is Disintegration Time of Enteric-coated table?
- Tablets which have Enteric-coating should not disintegrate for 2 hours in acidic media and then these tablets when placed in basic media should disintegrate within 1 hour.
16. What is the limit of friability
- Not more than 1%
17. Defects of Coating
- Sticking
- Colour variation
- Orange peel effect
- Logo filling
- Chipping
- Film cracking
18. Types of coating
- Film Coating
- Enteric Coating
- Sugar Coating
19. What is HVAC?
- Heating Ventilation and Air conditioning
20. Functions Of HVAC
- Prevent cross-contamination
- Maintain Temperature
- Maintain Humidity
- Create Differential Pressure
- Maintain Air Changes
21. Types of capsules
- Hard Gelatin Capsule
- Soft Gelatin Capsule
22. Revolution of Friability
- 25 rpm per minute and run-time is 4 minutes.
23. Name of 3 Natural binders
- Starch
- Cellulose
- Gelatin
24. Name of Synthetic Binder
- PVP k 30 or kollidon, povidone.
25. Why do we manufacture granules?
Granules are prepared for tablet compression because of the following main reasons.
- To enhance flow because powders flow is poor.
- To prevent weight variation.
- To reduce dusty environment because powders are dustier.
- To prevent segregation.
- To improve content uniformity.
- To improve compaction.
- Powders are elastic so tend to cap but granules are plastic so prevent tablet capping.
26. What is a rat hole?
- Rat hole is a powder flow defect in which powder adheres to the walls of compression machine hopper or blender walls and stops the flow against walls creating a hole in the middle. It results in weight variation and fragile tablets during compression.
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